Add the buttermilk and hot sauce to a medium-sized mixing bowl. Stir to combine. Add the tomato slices and soak for about 20 minutes.
In a breading tray or shallow container, whisk together the flour, cornmeal, salt, paprika, and pepper. Set aside until ready to use.
Add the oil to a skillet over medium-high heat and allow to come to temperature, between 350°-375°.
Shake off any dripping buttermilk from the tomatoes, and dredge completely in the dry batter. Carefully add to the oil, taking care not to overcrowd the pan and frying in batches as needed. Cook the tomatoes for 1 ½ -2 minutes each, or just until the crust is perfectly golden brown. Remove from the oil and allow to cool slightly. For best results, serve right away.