For the Spicy Ketchup sauce, combine ketchup, chili powder, cumin, pepper, Worcestershire and liquid smoke in a small mixing bowl, and whisk to combine. Set aside until ready to use.
For the turkey patties, have ready a pan lined with wax paper, and begin preparing the turkey patties. In a mixing bowl, combine turkey and TAK seasoning, and mix until well combined. With damp hands, take about 3 tablespoons of ground turkey, and roll into a ball in between the palms of your hands. Press the turkey ball flat like a pancake. Transfer to the wax paper, and continue making patties.
Once all of the turkey patties are formed, add 1 ½ tablespoon of oil to a large sauté pan over medium-high heat, and allow to come to temperature. Transfer patties to the pan and cook for 3 minutes. Do not overcrowd the pan. Flip the patty, add a generous pinch of cheese to the top of the patty and continue to cook for 2 ½ - 3 minutes more. Set aside.
Add another tablespoon of canola oil to the sauté pan (if necessary) before adding the onions. Reduce the heat to medium, add the onions and sauté the onion for about 6 minutes, or until softened and cooked through.
Assemble the patty melts by placing turkey patty on a slice of toasted wheat bread, top with a generous helping of onions and a spoonful of spicy ketchup sauce. Serve and enjoy.